Using various gene ontology databases, I have compiled a list of descriptions that can be attributed to human COL1A1. As shown below, these include the cellular component, molecular function, and biological processes this protein may be involved in. The ones I found to be most intriguing have been highlighted red for easier skimming. My analysis of these results is below. Cellular component GO #
Collagen 0005581 Collagen type I 0005584 Cytoplasm 0005737 Extracellular matrix 0031012 Extracellular region 0005576 Extracellular space 0005615 Plasma membrane 0005886 Molecular Function GO # Extracellular matrix structural constituent 0005201 Identical protein binding 0042802 Platelet-derived growth factor binding 0048407 Protein binding 0005515 Transcription activator activity 0016563 |
Biological Processes GO #
Axon guidance 0007411 Blood coagulation 0007596 Blood vessel development 0001568 Bone trabecula formation 0060346 Cartilage development involved in endochondral bone morphogenesis 0060351 Cellular response to growth factor stimulus 0071363 Cellular response to retinoic acid 0071300 Collagen biosynthetic process 0032964 Collagen fibril organization 0030199 Embryonic skeletal system development 0048706 Endochondral ossification 0001958 Face morphogenesis 0060325 Intramembranous ossification 0001957 Leukocyte migration 0050900 Negative regulation of cell-substrate adhesion 0010812 Osteoblast differentiation 0001649 Platelet activation 0030168 Positive regulation of canonical Wnt receptor signaling pathway 0090263 Positive regulation of cell migration 0030335 Positive regulation of epithelial to mesenchymal transition 0010718 Positive regulation of transcription, DNA-dependent 0045893 Protein heterotrimerization 0070208 Protein localization to nucleus 0034504 Protein transport 0015031 Response to cAMP 0051591 Response to corticosteroid stimulus 0031960 Response to hydrogen peroxide 0042542 Response to inorganic substance 0010035 Response to mechanical stimulus 0009612 Response to nutrient 0007584 Response to peptide hormone stimulus 0043434 Sensory perception of sound 0007605 Skeletal system development 0001501 Skin morphogenesis 0043589 Tooth mineralization 0034505 Visual perception 0007601 |